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Neuro-Oncology Advances
OMRT-5. Therapy-induced reprogramming drives glioma vascular transdifferentiation and recurrence2021 •
Therapy-resistant glioma cells elicit remarkable phenotypic plasticity leading to aggressive tumor recurrence. Here, we used single-cell and whole transcriptomic sequencing to uncover that radiation treatment induces a dynamic shift in functional states of glioma cells allowing for acquisition of either stem-like, mesenchymal-like or vascular-like phenotypes. The predominant phenotype switch induced by radiation in surviving tumor cells is the vascular-like cell state, resulting in transdifferentiation to endothelial-like and pericyte-like cells in distinct cell clusters. The transdifferentiated endothelial-like and pericyte-like cells secrete trophic factors to support proliferation of tumor cells, and their selective ablation results in reduced tumor growth and recurrence post-treatment. Mechanistically, the acquisition of vascular-like phenotype is driven by increased acetylation and chromatin accessibility in vascular genes and in regions for binding of vascular specification tr...
2019 •
Journal of Dental Hygiene and Therapy
Socio-Cultural Factors That Affect the Oral Health of Adolescent (Systematic Review)2022 •
Journal of the American Board of Family Medicine
Surveying Adolescents Enrolled in a Regional Health Care Delivery Organization: Mail and Phone Follow-up--What Works at What Cost?2010 •
2010 •
International Immunology
Mycophenolic acid-treated dendritic cells generate regulatory CD4+ T cells that suppress CD8+ T cells' allocytotoxicity2014 •
Micromachines
Composites, Fabrication and Application of Polyvinylidene Fluoride for Flexible Electromechanical Devices: A Review2020 •
Journal of health, population, and nutrition
Arsenic exposure from drinking-water and carotid artery intima-medial thickness in healthy young adults in Bangladesh2006 •
Epidemiological studies have linked high levels (>200 microg/L) of chronic exposure to arsenic in drinking-water with elevated risks of several vascular diseases. In this pilot study, the association between low-level arsenic exposure and carotid artery intimal-medial thickness (IMT) was evaluated among 66 healthy, normotensive, relatively young individuals (mean age 35 years) participating in the ongoing Health Effects of Arsenic Longitudinal Study in Bangladesh. Participants with a higher carotid IMT (>0.75 mm) in general had higher levels of past chronic exposure of arsenic than those with a lower carotid IMT (< or = 0.75 mm). Although the differences in average arsenic exposure between the two groups were not statistically significant, the findings suggest a possible association between low-level arsenic exposure from drinking-water and carotid atherosclerosis, warranting the need for larger studies.
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Journal of Biological Chemistry
Skin-type Antifreeze Protein from the Shorthorn Sculpin, Myoxocephalus scorpius. EXPRESSION AND CHARACTERIZATION OF A Mr 9,700 RECOMBINANT PROTEIN1998 •
The Journal of Poultry Science
The Effect of Malic Acid on Performance and Some Digestive Tract Traits of Japanese Quails2009 •
2010 •
Journal of Hard Tissue Biology
Effects of Gaseous Ozone Treatment on Bone Regeneration in Femoral Defect Model in Rats2017 •
Applied Physics Letters
Al-doped HfO2/In0.53Ga0.47As metal-oxide-semiconductor capacitors2011 •
New Zealand Journal of Geology and Geophysics
Derivation of the older moraines in Beacon Valley, Antarctica: Comment1974 •
Harati: Jurnal Pendidikan Kristen
Sumbangsih Pendidikan Israel Kuno Dalam Pendidikan Agama Kristen Pada AnakIEEE Journal of Emerging and Selected Topics in Power Electronics
Pareto Optimal Weighting Factor Design of Predictive Current Controller of a Six-Phase Induction Machine Based on Particle Swarm Optimization Algorithm2021 •