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2019 •
Bien que les systemes actuels de General Game Playing (GGP) facilitent la recherche en Intelligence Artificielle (IA) autour des jeux, ils sont souvent trop specialises et fournissent une capacite de calcul trop faible. Cet article decrit une premiere version du systeme ludemique de GGP denomme LUDII qui apporte un outil efficace a la recherche en IA tout autant qu’aux concepteurs de jeux ou aux historiens mais aussi dans bien d’autres domaines. LUDII definit les jeux comme des arbres de ludemes, correspondant a des concepts et mecanismes de jeu de haut niveau et facilement interpretables. Nous etablissons les bases de LUDII en analysant ses principaux avantages : generalite, extensibilite, comprehensibilite et efficacite. Experimentalement, LUDII surpasse l’un des plus performants raisonneurs decrit avec le General Game Description Language (GDL), base sur un reseau de propositions (propnet), pour tous les jeux disponibles sur le serveur GGP.
2016 •
A rich and complex structural diversity is uncovered in the microsolvation of the nitrate anion.
Journal of Cell Biology
CDK4 regulation by TNFR1 and JNK is required for NF-κB–mediated epidermal growth control2005 •
Nuclear factor κB (NF-κB) mediates homeostatic growth inhibition in the epidermis, and a loss of NF-κB function promotes proliferation and oncogenesis. To identify mechanisms responsible for these effects, we impaired NF-κB action in the epidermis by three different genetic approaches, including conditional NF-κB blockade. In each case, epidermal hyperplasia was accompanied by an increase in both protein levels and tissue distribution of the G1 cell cycle kinase, CDK4. CDK4 up-regulation required intact TNFR1 and c-Jun NH2-terminal kinase (JNK) function. Cdk4 gene deletion concomitant with conditional NF-κB blockade demonstrated that CDK4 is required for growth deregulation. Therefore, epidermal homeostasis depends on antagonist regulation of CDK4 expression by NF-κB and TNFR1/JNK.
2019 •
Esta pesquisa empirica, de carater exploratorio, procura revelar os indicios de visibilidade vulneravel e de uma fragil interacao quando se observa a pagina de uma entidade estatal (Prefeitura) no Facebook . Por meio da analise dos dados quantitativos extraidos com o aplicativo Netvizz, percebe-se que: 1) a visibilidade presente na pagina e voltada preferencialmente para as acoes que a prefeitura realiza na cidade e informacoes que visam apenas a promocao de uma imagem que os proprios cidadaos questionam; e 2) a interacao da Prefeitura com o cidadao ludovicense e fragil, ja que nao aproveita toda a potencialidade da pagina enquanto ferramenta para construcao de pontes com o cidadao.
Proceedings of the National Academy of Sciences
Comparative genomics reveals mechanism for short-term and long-term clonal transitions in pandemic Vibrio cholerae2009 •
Vibrio cholerae , the causative agent of cholera, is a bacterium autochthonous to the aquatic environment, and a serious public health threat. V. cholerae serogroup O1 is responsible for the previous two cholera pandemics, in which classical and El Tor biotypes were dominant in the sixth and the current seventh pandemics, respectively. Cholera researchers continually face newly emerging and reemerging pathogenic clones carrying diverse combinations of phenotypic and genotypic properties, which significantly hampered control of the disease. To elucidate evolutionary mechanisms governing genetic diversity of pandemic V. cholerae , we compared the genome sequences of 23 V. cholerae strains isolated from a variety of sources over the past 98 years. The genome-based phylogeny revealed 12 distinct V. cholerae lineages, of which one comprises both O1 classical and El Tor biotypes. All seventh pandemic clones share nearly identical gene content. Using analogy to influenza virology, we defin...
International Journal of Infectious Diseases
56 Changing patterns in the risk for Cytomegalovirus infection and disease and treatment-related outcomes in the Era of preemptive antiviral therapy2006 •
Drug Discovery Today
Bilosomes in the context of oral immunization: development, challenges and opportunities2016 •
International Journal of Energy Economics and Policy
Effects of Targeting Energy Subsidies on Domestic Electricity Demand in Iran2017 •
The ever-increasing electricity consumption in Iran, mainly due to its low and, in fact, unrealistic price, has caused the nationwide power supply network to fail meeting the demand; therefore, optimizing its price is an important issue in the management of the electricity supply and demand. Domestic energy consumption is very high in the country making it a necessity to optimize it and study the consumer’s behavioral reaction towards the variations of the electricity price. Effort has been made in this paper to study the impact of the targeting of energy subsidies on domestic demand during 1991-2012 using the almost ideal demand system and seemingly unrelated regression estimation methods. Results have shown that electricity is an essential commodity for both urban and rural families; the absolute value of the price elasticity has been found to be less than unity for both. Results have also indicated that the consumption reaction against the price increase is not much. It is conclu...
Revista Estudios Juridicos Segunda Epoca
Mutilación Genital Femenina: Violencia De Género Con Nuevas Trabas Para Su Persecución en España2014 •
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PLOS Neglected Tropical Diseases
Correction: Affinity Is an Important Determinant of the Anti-Trypanosome Activity of Nanobodies2012 •
Research Square (Research Square)
Transferrin Predicts Trimethylamine-N-Oxide Levels and is a Potential Biomarker of Cardiovascular Disease2022 •
Social Work and Social Sciences Review
´In Good Spirits´ and the Achievement of Material Satisfaction: Evidence from Argentina2019 •
arXiv (Cornell University)
A new smoothing method for nonlinear complementarity problems involving P0 function2022 •
Fertility and Sterility
The Changing Practice Pattern of Infertility Care in the U.S2000 •
Journal of Craniofacial Surgery
Metastasis of Prostate Adenocarcinoma in the Mandible2020 •
International Journal of Lightweight Materials and Manufacture
Development and application of nanocomposite for sustainable rail vehicle with low environmental footprint2020 •